Crystal structure of SIV matrix antigen and implications for virus assembly
Identifieur interne : 004094 ( Main/Exploration ); précédent : 004093; suivant : 004095Crystal structure of SIV matrix antigen and implications for virus assembly
Auteurs : Zihe Rao ; Alexander S. Belyaev ; Elizabeth Fry ; Polly Roy ; Ian M. Jones ; David I. StuartSource :
- Nature [ 0028-0836 ] ; 1995-12-14.
Abstract
SIMIAN immunodeficiency virus (SIV) is closely related to human immunodeficiency virus (HIV)1, their matrix antigens (MAs) sharing some 50% sequence identity. MA is a component of PrSSGag, the sole protein required for assembly of the virion shell2. MA targets Pr55 to the plasma membrane3, and facilitates incorporation of the virus envelope protein4 and assembly of the PrSSGag shell5. Cleavage of PrSS by the viral protease produces the mature protein of relative molecular mass 1718K, which underlies the host-derived membrane and is important in both virus entry6 and nuclear localization of the virion core7. Here we report the crystal structure of SIV MA. The molecule forms a trimer consistent with oligomerization in vitro8, the observed virion architecture9, and various biological properties of MA.
Url:
DOI: 10.1038/378743a0
Affiliations:
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Belyaev</name></author><author><name sortKey="Fry, Elizabeth" sort="Fry, Elizabeth" uniqKey="Fry E" first="Elizabeth" last="Fry">Elizabeth Fry</name></author><author><name sortKey="Roy, Polly" sort="Roy, Polly" uniqKey="Roy P" first="Polly" last="Roy">Polly Roy</name></author><author><name sortKey="Jones, Ian M" sort="Jones, Ian M" uniqKey="Jones I" first="Ian M." last="Jones">Ian M. Jones</name></author><author><name sortKey="Stuart, David I" sort="Stuart, David I" uniqKey="Stuart D" first="David I." last="Stuart">David I. Stuart</name></author></analytic><monogr></monogr><series><title level="j" type="main">Nature</title><imprint><publisher>Nature Publishing Group</publisher><date when="1995-12-14">1995-12-14</date><biblScope unit="vol">378</biblScope><biblScope unit="issue">6558</biblScope><biblScope unit="page" from="743">743</biblScope><biblScope unit="page" to="747">747</biblScope><date type="Copyright" when="1995">1995</date></imprint><idno type="ISSN">0028-0836</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0028-0836</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">SIMIAN immunodeficiency virus (SIV) is closely related to human immunodeficiency virus (HIV)1, their matrix antigens (MAs) sharing some 50% sequence identity. MA is a component of PrSSGag, the sole protein required for assembly of the virion shell2. MA targets Pr55 to the plasma membrane3, and facilitates incorporation of the virus envelope protein4 and assembly of the PrSSGag shell5. Cleavage of PrSS by the viral protease produces the mature protein of relative molecular mass 1718K, which underlies the host-derived membrane and is important in both virus entry6 and nuclear localization of the virion core7. Here we report the crystal structure of SIV MA. The molecule forms a trimer consistent with oligomerization in vitro8, the observed virion architecture9, and various biological properties of MA.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Belyaev, Alexander S" sort="Belyaev, Alexander S" uniqKey="Belyaev A" first="Alexander S." last="Belyaev">Alexander S. Belyaev</name><name sortKey="Fry, Elizabeth" sort="Fry, Elizabeth" uniqKey="Fry E" first="Elizabeth" last="Fry">Elizabeth Fry</name><name sortKey="Jones, Ian M" sort="Jones, Ian M" uniqKey="Jones I" first="Ian M." last="Jones">Ian M. Jones</name><name sortKey="Rao, Zihe" sort="Rao, Zihe" uniqKey="Rao Z" first="Zihe" last="Rao">Zihe Rao</name><name sortKey="Roy, Polly" sort="Roy, Polly" uniqKey="Roy P" first="Polly" last="Roy">Polly Roy</name><name sortKey="Stuart, David I" sort="Stuart, David I" uniqKey="Stuart D" first="David I." last="Stuart">David I. Stuart</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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